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Genetic Cause of Polycystic Kidney Disease

Many people with Polycystic Kidney Disease at childbearing age are told that their children may been at a high risk of this disease, because PKD is an inherited kidney disease. Then, they want to know genetic cause of Polycystic Kidney Disea

The Doctor Answered:

Genetic Cause of Polycystic Kidney DiseaseAccording to the different inherited ways, Polycystic Kidney Disease is divided into two types: autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) The onset of ADPKD can be any age especially in adult, while ARPKD usually appears in child. Because ADPKD is more common, today we mainly talk about the genetic cause of ADPKD.

Until, two genes are found to have a close link with ADPKD: PKD1 and PKD2. Mutations in either PKD1 or PKD2 can cause this common type of PKD. The PKD1 gene is located on chromosome 16, while the PKD2 gene is located on chromosome 4. Both of these two genes are involved in transmitting chemical signals from the outside of the cell to the cells’s nucleus. Kidney disease scientists believe that these two kinds of proteins work together to promote normal kidney development and function. Once these genes become abnormal, ADPKD occurs easily.

In most cases, children whose parents have PKD have a 50% chance to get this disease. If you are suffering from this disease, consulting doctor online is very necessary to guarantee the health of your children.

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