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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

Can You Stop Medicine When High Creatinine Is Reduced and Proteinuria Turns Negative

2018-08-25 08:45

Can You Stop Medicine When High Creatinine Is Reduced and Proteinuria Turns NegativeThere are often such questions as:

Should patients with renal insufficiency eat medicine for all their life?

The side effect of steroid is so serious, when can I stop taking it?

ACEI or ARBs can protect kidney function well, but can I not take them?


As a matter of fact, the indication of drug withdrawal in renal patients is not determined by such cases as "urine protein turns to negative", "normal blood pressure" or "creatinine reduction", but comprehensive consideration, such as primary disease, pathological type, steroid dependence, how low blood pressure can be reduced, side effects, and total duration of medication. Otherwise, drug withdrawal can speed up kidney failure.

If the above treatment effect is achieved, what conditions can be achieved to stop taking drugs?

Nephrotic Syndrome or Membranous Nephropathy patients who use steroids effectively: the total duration of hormone use is usually more than a year and a half, or even more than two years, but the amount of hormones will be smaller and smaller, and the rate of reduction will be slower until the hormone is completely stopped. And those auxiliary medicine such as jinshuibao, zhiling capsule, or yupingfeng or calcium tablets can be stopped gradually.

Patients with steroid-dependence: prolonged use of immunosuppressive agents is required at this point, while individualized hormone therapy is maintained for a long time and can be discontinued if necessary.

Patients with Lupus Nephritis: After the condition is stabilized, hormone dosage can be reduced until it is the minimum dosage. Keep on the minimum dosage. It is mainly for the prevention of relapse. The normal daily dose is 5-10mg prednisone tablets.

Kidney patients with adverse reactions caused by taking immunosuppressive drugs: when white blood cells are significantly reduced or liver function is seriously damaged, the above drugs should be temporarily stopped. When white blood cells recover and liver function is improved, decision is to made whether it should continue to be used or not.

Membranous nephropathy patients: during stage 1-2, after taking hormones and immunosuppressive agents, the effect is very good. However, in stages 3-4 of membranous nephropathy, most patients have poor efficacy. For example, if the use of the hormone "sufficient dose and sufficient time" still has no obvious effect, it is recommended to reduce the hormone rapidly until the use of the hormone is completely stopped.

Chronic renal insufficiency or uremia patients: the principle should be long-term medication. In addition to use western medicine for hypertension, phosphorus, anemia, uric acid and other symptoms, Chinese patent medicine or herbal medicine is often used together to reduce inflammation, prevent fibrosis and eliminate turbidity by purgation.

For patients with chronic kidney disease, it is recommended to take ACEI or ARBs for a long time to reduce urinary protein, protect renal function and delay the progression of kidney disease.

Chronic kidney disease is prone to recurrence and has a high risk of uremia. Therefore, drugs and examinations are indispensable, and the drug withdrawal must not be self-assertion, otherwise you are the one to be injured eventually.

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