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Medullary Cystic Kidney Disease: Causes, Symptoms and Treatments

2013-06-10 15:10

Medullary cystic kidney disease (MCKD), not as common as PKD, is another inherited condition where cysts developing in the center of each kidney cause kidney to fail gradually. Therefore, for people with MCKD, knowing its causes, symptoms and treatments is very necessary.

Medullary cystic kidney disease causes

This disease is inherited in an autosomal dominant pattern, so the abnormal gene is its root cause. According to the onset time, MCKD is divided into to types. Type 1 has a median onset of kidney failure at age 62, and it is caused by defects in the MCKD1 gene. Type 2 has an earlier onset of ESRD at about age 32, and it is caused by defects in the MCKD2 gene.

In these conditions, kidney urine concentration and acidic function declines easily, so some symptoms may occur to warn people to get test and treatment timely.

Medullary cystic kidney disease symptoms

● Frequent urination at night

● Thirsty all the time

● Weakness

● Muscle cramps

● Nausea, vomiting blood or blood in the stool


● Skin may appear yellow or brown

● Declined sensation in hands, feet or other areas

● Weight loss

● Coma

There are many other symptoms that may occur. If you or your children have some of the above symptoms, make sure to make an accurate diagnosis and get prompt treatment.

Medullary cystic kidney disease treatments

Different from cysts in renal cortex and pelvis, cysts in the renal medulla are difficult to deal with. Firstly, the surgery is impossible to cut off them because it is very dangerous. Therefore, the treatment focuses on well control of patients’ symptoms and shrink renal medullary cysts.

To shrink these cysts, the osmosis therapy, an external application remedy, can be helpful, because during this treatment, medicines, which are proven to have an effect on drying kidney cysts, are crushed and then placed into two small machines. When these two small machines is put on patients’ back, the pesticide effect can reach the kidney cysts directly. Finishing the treatment, patients’ condition can be improved largely.

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