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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

Is Anaemia Indicative of Kidney Failure

2018-07-25 08:24

Is Anaemia Indicative of Kidney Failure?Does Anemia indicate kidney failure? 3 methods help you treat anemia well. When anemia is under control, your complications will be reduced greatly.

Anaemia is very common in patients with chronic kidney disease, and the incidence increases with the decline of renal function. By CKD stage 5, anaemia is already extremely common.

Renal anemia refers to anemia caused by insufficient production of renal erythropoietin due to various reasons or partial toxic substances of uremia that interfere with the production and metabolism of erythrocytes. It is a common complication of chronic renal failure.

Currently, there are six main causes of renal anemia.

1. Lack of erythropoietin or relative deficiency in erythropoietin production

More than 90 percent of erythropoietin is produced by kidney tissue, so erythropoietin deficiency due to renal failure is the main cause of anemia.

2. Erythrocyte growth suppressor

When you enter the uremia phase, certain substances in the blood can inhibit erythropoietin production so as to cause anemia.

3. Red blood cell life is shortened

As a result of extracellular factors, the red blood cell life of renal failure patients is shortened, and this condition will be improved after dialysis.

4. Bleeding

Patients with renal failure often have bleeding, such as bleeding from the gums, and the inability of the gastrointestinal tract to absorb iron causes the body to lack iron, leading to renal anemia.

5. Iron and folic acid deficiency

For example, patients with chronic renal failure have coagulative dysfunction, or dialysers leak blood during hemodialysis.

6. Toxin interference

When entering uremia, the concentration of toxins in the body increases, and these toxins interfere with the production and metabolism of red blood cells, leading to renal anemia.

How to improve renal anemia?

-Iron supplement

Non-dialysis patients and patients with peritoneal dialysis can be given iron supplements by oral administration at a dose of 200mg/d, and the iron status can be re-evaluated after 1-3 months. If the iron status and hemoglobin do not reach the target value (ESAs100~150IU/kg per week), or if the oral iron dose is not tolerated, the iron supplements can be replaced by intravenous administration.

-Intravenous iron

Hemodialysis patients should be given intravenous iron. Dose of a course is 1000 mg. After completion of a course of treatment, if serum ferritin is still<=500 ug/L and TSAT is still <=30%, you can repeat a course of treatment. After the iron status reach the normal range, the dose and time of iron supplement should be adjusted according to the patient's response to iron, hemoglobin levels and so on. It is suggested that 100 mg once every 1 ~ 2 weeks.

-Erythrocytic stimulant therapy

For hemodialysis and non-hemodialysis patients with chronic kidney disease, the initial dose of recombinant human erythropoietin is recommended to be 50-100iu /kg three times a week or 10000IU once a week by subcutaneous or intravenous.

Hemoglobin levels should be monitored at least once a month during the initial treatment period. During maintenance treatment, hemoglobin should be monitored at least once every 3 months for CKD patients without dialysis, and hemoglobin should be monitored at least once a month for patients with CKD stage 5.

Now you have anemia and renal failure clearly. If you still have any questions on anemia, medications, indicators and other information associated with renal failure, please leave a message below or contact online doctor.

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