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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

How Does Proteinuria Cause Kidney Damage

2018-09-26 09:46

How Does Proteinuria Cause Kidney DamageMost kidney patients deal with urinary protein from the time they develop kidney disease, and not until uremia they can not get rid of urinary protein. Because they are so familiar with urinary protein that they usually lower their guard and the treatment become optional.

But do you know how harmful urinary protein is to the kidneys?

In the clinical practice of nephrology, urinary protein has been regarded as the first independent factor leading to uremia. The occurrence of urinary protein, on the one hand, is due to the massive loss of nutrition; on the other hand, urinary protein can also cause damage to renal tissues such as glomeruli and renal tubules, gradually causing renal fibrosis and eventually leading to uremia.

According to the pathological site of kidney patients, there are roughly four ways of renal injury by urinary protein:

1. Proximal convoluted tubules are damaged

After the occurrence of urinary protein, the leakage of macromolecular protein will enter the renal tubule, resulting in increased protein content in renal tubular epithelial cells, which can trigger a large amount of activation of lysosome. Lysosome overflows into the tubule cytoplasm, resulting in inflammatory response and renal scar.

2. Mesangial cells are damaged

As kidney disease progresses, urine protein deposits in the mesangial region of the kidney, leading to damage and proliferation of mesangial cells so as to lead to the appearance of glomerular sclerosis. In addition, the accumulation of apolipoprotein B and apolipoprotein A in low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in the glomeruli can also lead to glomerular sclerosis.

3. Cell hypoxia

When urine protein leaks out, the body will reabsorb it to a certain extent, and at the same time, the consumption of a large amount of protein also needs energy support. With more use of these tasks, the oxygen of renal tubular cells will reduce, causing cell damage.

4. Cell proliferation

Diseased kidneys develop an inadaptive response to urinary protein - cell proliferation, a major cause of kidney failure. Because urinary protein can regulate the function of glomeruli cells directly, change the growth characteristics and protein gene expression of cells, trigger cell proliferation, induce cell fibrosis, and accelerate renal failure.

How to treat proteinuria?

The core idea for the treatment of urinary protein is to suppress the inflammatory response of the immune system in the body and to block the progression of renal fibrosis as much as possible. Steroids (such as prednisone, prednisone, methylprednisolone, etc.) are very effective in treating proteinuria, but they have many side effects. At the same time, it is necessary to use the combination of ACEI or ARBs, which do not only lower blood pressure, but also protect renal function. If you are not sensitive to steroids, try an immunosuppressant.

Western medicine is only to control symptoms, so you had better choose some other treatment, such as Foot Bath and Steam Therapy. They can protect renal function and prevent the deterioration of kidney disease.

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