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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

What Are the Effects of Resveratrol on PKD

2014-06-20 00:36

What Are the Effects of Resveratrol on PKDResveratrol is a member of a group of plant compounds called polyphenols. It can be seen in many herbs, and commonly seen in grapes and red wines. Resveratrol’s effects on protecting cardiovascular and preventing cancers have been proved by many clinical practices. However, what are the effects of resveratrol on Polycystic Kidney Disease (PKD)?

► Benefits

The greatest effect of resveratrol is its antioxidative properties. Resveratrol is known to be a robust scavenger of reactive oxygen species (ROS). In addition to scavenging ROS, resveratrol may have numerous protective effects against age-related disorders, including renal diseases. In this way, the glomerular mesangial cells can be protected. Previous reports have shown that resveratrol can ameliorate several types of renal injury, such as Diabetic Nephropathy, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, and sepsis-related injury. PKD patients always have low immunity. This is why so many PKD patients always complain they get sick easily. Antioxidants can boost their immunity and then help them get rid of illness.

► Side effects

Well then, is resveratrol is absolutely safe for PKD patients? No. Even though studies have not discovered any severe side effects when resveratrol is taken in large doses, resveratrol supplements might interact with blood thinners such as warfarin, and nonsteroidal anti-inflammatory medications such as aspirin and ibuprofen, increasing the risk of bleeding.

► Dosage

What’s more, like other supplements, resveratrol is not regulated by the FDA, so it is difficult for consumers to know exactly what they are getting when they buy a bottle, or whether the product is actually effective. There also isn't any specific dosage recommendation, and dosages can vary from supplement to supplement.

The dosages in most resveratrol supplements are typically far lower than the amounts that have been shown beneficial in research studies. Most supplements contain 250 to 500 milligrams of resveratrol. To get the equivalent dose used in some animal studies, people would have to consume 2 grams of resveratrol (2,000 milligrams) or more a day.

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