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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

Polycystic Kidney Disease and Elevated BUN

2013-06-07 11:55

Polycystic Kidney Disease and Elevated BUNBlood urea nitrogen (BUN) along with creatinine is the most widely used blood test for the evaluation of kidney function. Generally, the higher BUN level is, the lower kidney function. For people with PKD, elevated BUN is one of their big concerns. If you are also faced with this problem, you can get an overview understanding of Polycystic Kidney Disease and elevated BUN from this article.


Urea nitrogen is the final degradation product of protein and amino acid metabolism. Normally, healthy kidneys are responsible for the excretion of urea. Polycystic Kidney Disease is chronically progressive, so in the early stage, PKD patients’ kidneys can still work optimally. However, high BUN may appear in any stage of Polycystic Kidney Disease, because the build up of excessive urea is associated with not only low kidney function level but also your protein intake, mental stress and so on.

If you are tested out elevated BUN but still have more than 50% kidney function, your abnormal blood test may be due to the following factors:

● Dehydration

● Excessive protein intake

● Shock

● Hemorrhage into the gastrointestinal tract

● Stress

● Acute myocardial infarction

However, if your kidney function is damaged badly by large kidney cysts, your abnormal BUN level must have a close link with your impaired renal function.

How to lower high BUN for PKD?

Since the underlying causes of elevated BUN are so different, it is quite necessary for you to get an accurate diagnosis before taking any management.

If your high BUN appears in the early stage of PKD, developing a low-protein diet, drinking plenty of fluids daily to stay hydrate, doing some soft exercise to ease your stress, etc, are helpful. As for the detailed modifications of diet or lifestyle, you need to describe your illness briefly for the online doctor so that they can help you make a healthy diet and exercise plan.

If your high BUN appears in the moderate or end stage of PKD, the treatment that can both purify blood and repair damaged kidney cells is the best choice. Until now, only Immunotherapy has such an effect. After the treatment, patients with PKD all find their kidney function is improved largely.

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