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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

Can Vitamin B3 Help Shrink Kidney Cyst in PKD

2013-07-01 10:23

Can Vitamin B3 Help Shrink Kidney Cyst in PKDIf you or your lovers are suffering from Polycystic Kidney Disease, you may have heard that vitamin B3 can help shrink cyst in PKD. Why do people come up with this view? How does vitamin B3 work?

Pathophysiology of PKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common life-threatening genetic diseases. Mutations in PKD1 and PKD2 is the root cause of PKD. The recent researches report that SIRT1 which contains at least 7 unique proteins affects the onset of PKD. This is because the protein expression of SIRT1 is increased in the mutant renal epithelial cells and tissues of PKD1.

In conclusion, SIRT1 can determine the formation and growth of cyst in Polycystic Kidney Disease largely.

Vitamin B3 and kidney cyst in PKD

First of all, vitamin B3, also called nicotinamide, is proven to be safe and effective on treating PKD, through inhibiting the activity of SIRT 1, because the decline of this protein can slow down the formation and growth of kidney cysts.

Additionally, vitamin B3 is a commonly used supplement with little toxicity, so it can also work for infants who are genetically at risk for developing PKD.

How do PKD patients get enough vitamin B3?

Vitamin B3 is stable in some foods such as animal liver and kidney, lean meat, whole grain, bean, dairy products, green vegetables, etc. General population may get enough vitamin B3 from these foods, if necessary, some medicines. However, for people with Polycystic Kidney Disease, the situation may be different, because a kidney good diet urges them to avoid some foods such as animal liver and kidney.

Besides, the correct does of vitamin B3 intake is also very important, since excess dosage is more likely to cause some side effects such as mild fever, nausea, vomiting, dizziness, dry skin, skin itching, high blood sugar, arrhythmia.

In view of this, if you have PKD and want to treat your disease with the help of vitamin B3, you had better describe your condition briefly to the online doctors, so they can tell you which and how much foods high in this vitamin you can eat, and whether you need some medicines.

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