Macrophage Migration Inhibitory Factor Promotes Cyst Growth in Polycystic Kidney Disease

2015-09-13 01:59

Polycystic kidney disease is a genetic disorder, and cyst grows and enlarges by the time, which may cause kidney damage and lead to kidney failure in the end. How to control growth is the key to treatment of kidney cyst. Here we will explain how macrophage migration inhibitory factor (MIF) promotes cyst growth for you.

To tell the truth, it is not clear very much that how and what promotes cyst growth in PKD. But MIF is proved to have close connections with cyst growth, and maybe plays an important role. Research shows that MIF increases in lining epithelial cells of cyst for polycystin-1-deficient murine kidney. In addition, MIF builds up in cyst fluids for patients with PKD.

Besides, MIF makes epithelial cells get increased by stimulating ERK, MTOR and Rb/E2F pathway and by elevating glucose and ATP production. In polycystin-1-deficient mice, MIF was demanded for calling and retention of kidney macrophages, which made cyst get expanded. This research indicates that MIF plays a very important role in controlling PKD pathogenesis.

In daily life, patients with PKD should prevent kidney cyst from growing to avoid kidney failure. A healthy diet and lifestyle is necessary, and they need have a low protein, low phosphorus, low potassium and low salt diet, and avoid smoking, staying up, drinking much. Getting proper medical treatment should be immediate and effective to prevent deterioration of PKD condition.

Chinese medicine is very effective to shrink kidney cyst by preventing secretion of cyst fluids and enhance permeability of cyst walls to let cyst fluids get out more easily. In this way, cyst will be shrunk very effectively. What is more, kidney condition can be improved with Chinese medicine by promoting blood circulation, expanding blood vessels, preventing inflammation and degrading fibrosis. More information or any question, welcome to leave a message or contact online doctors anytime. Reply will be given very fast in detail for you.

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